• SOURCE: AstraZeneca - US

The Importance Of BRCA Testing For Ovarian Cancer



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ANCHOR LEAD: For women diagnosed with ovarian cancer, genetic testing can help inform appropriate treatment decisions. Brian Osuch has the details. (2:00) SCRIPT: Screening on family history or age, misses many ovarian cancer patients with a BRCA mutation. Dr Ursula Matulonis, Medical Director of Gynecologic Oncology at the Dana-Farber Cancer Institute in Boston: CUT: (Dr Matulonis) Nearly half of BRCA-positive ovarian cancer patients have no significant family history of ovarian cancer. That's why it's so important for all women with ovarian cancer to be tested. For women with advanced ovarian cancer who have received previous treatment with 3 or more prior chemotherapies and who have an inherited mutation in the BRCA gene, LYNPARZATM (olaparib) may be one of those options. SCRIPT: If you have ovarian cancer, ask your doctor about the BRCA mutation. For more information, listen to the following Important Safety Information and go to Lynparza.com. There are no contraindications for LYNPARZA. LYNPARZA may cause serious side effects that can lead to death including bone marrow problems and lung problems. Some people who have ovarian cancer or who have received previous treatment with chemotherapy or certain other medicines for their cancer have developed bone marrow problems called Myelodysplastic syndrome (MDS) or Acute Myeloid Leukemia (AML) during treatment with LYNPARZA. If you develop MDS or AML, your healthcare provider will stop treatment with LYNPARZA. You will undergo blood tests before, and every month during, treatment with LYNPARZA to monitor your blood cell counts. Weekly blood tests will be performed if you have low blood cell counts that last a long time. Your healthcare provider may stop treatment with LYNPARZA until your blood cell counts improve. Tell your healthcare provider if you have any new or worsening symptoms of lung problems, including shortness of breath, fever, cough, or wheezing. Your healthcare provider may do a chest x-ray if you have any of these symptoms. Your healthcare provider may temporarily or completely stop treatment if you develop pneumonitis. You should not become pregnant during treatment with LYNPARZA. Talk to your healthcare provider if you are pregnant or plan to become pregnant. Avoid grapefruit, grapefruit juice and Seville oranges during treatment as they may increase the levels of LYNPARZA in your blood. The most common side effects are anemia, nausea or vomiting, tiredness or weakness, diarrhea, indigestion or heartburn, headache, loss of appetite, changes in how food tastes, changes in kidney function blood tests, sore throat or runny nose, upper respiratory infection, cough, pain in the joints, muscles, and back, rash, and pain or discomfort in the stomach area. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of LYNPARZA. For more information, ask your healthcare provider or pharmacist. For complete Prescribing Information, visit LYNPARZA dot com, or call 1-800-236-9933. That's Newsbreak from AstraZeneca.
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